By Philippe Derreumaux
Alzheimer's sickness is the commonest type of senile dementia, affecting greater than 24 million humans around the world. it truly is characterized pathologically through abnormally excessive degrees of neurofibrillary tangles due to the buildup of tau protein in useless and loss of life neurons, and through increased numbers of senile plaques within the cortex and hippocampus of the mind. the most important part of senile plaques is a small protein of 39–43 amino acids known as amyloid-β (Aβ). to date, no therapy has been proven to gradual the development of sporadic and familial Alzheimer's disease.
A huge physique of proof issues, in spite of the fact that, to the early Aβ-formed oligomers because the fundamental poisonous species in Alzheimer's ailment. a strong method for constructing pharmaceutical remedies opposed to Alzheimer's is to clarify the pathways of oligomer formation and ensure the constructions of the poisonous aggregates.
This ebook presents a wide ranging view throughout contemporary in vitro and in vivo reports in addition to state of the art machine simulations, designed to extend the readers' figuring out of Aβ oligomerisation and fibril formation. while, the e-book delves into the pathogenesis of familial and sporadic Alzheimer's ailment on the atomic point of detail.
Written by way of top authors of their respective fields, this ebook can be important to all scientists engaged on Alzheimer's disease.
Readership: common public, PhD scholars, postdocs, in addition to all scientists operating within the following fields: Alzheimer's ailment, amyloids, neuroscience, oligomers, protofibrils, fibrils, toxicity, constructions, dynamics, kinetics, thermodynamics, all-atom and coarse grained simulations, biophysics, reminiscence, studying, transgenic mouse types, steel ions, membrane, nanoparticles, computational chemistry, drug layout and bioinformatics.
Read or Download Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry) PDF
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Extra resources for Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry)